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Cambridge Centre for Parkinson-Plus


My research interests include the role of epigenetic mechanisms in neurodegeneration, and particularly in Lewy Body Dementia, Alzheimer’s disease and mild cognitive impairment. My projects focus on genome-wide profiling of DNA methylation and hydroxymethylation in post-mortem brain tissues and also in peripheral blood. Exploring disease driven changes in the epigenetic landscape has the potential to improve our understanding of the pathophysiology of neurodegenerative disorders and aid in the identification of novel pathways as therapeutic targets. Work on peripheral epigenetic profiling in combination with multimodal neuroimaging techniques can aid in the development of early risk markers of disease before the onset of any symptoms.

(O'Brien Lab/ The Old Age Psychiatry Research Group at University of Cambridge)
NIHR Clinical Lecturer
Not available for consultancy