Elijah Mak

Elijah Mak is an Alzheimer's Society and Lewy Body Society Fellow at the Department of Psychiatry's Old Age Psychiatry Group. His research focuses on the use of multi-modal neuroimaging techniques to map the topography of cerebral structural and functional changes in groups of people with neurodegenerative diseases as well as cognitively normal midlife adults at varying levels of risk (i.e, presence of APOE4 gene). His current research focuses on the following topics:The contributions of Alzheimer's disease copathologies to imaging and clinical phenotypes in people with Lewy bodies, as measured by plasma biomarkers and/or PET imaging.Using Neurite Orientation Dispersion and Density Imaging and Neuromelanin-MRI to detect early cortical microstructural changes in Lewy body dementia.This multi-modal approach could aid in the validation of emerging imaging biomarkers to track disease progression over time, as well as understanding the differential contributions of various pathological processes and how they might underpin cognitive impairment.