Research
Neurodegenerative diseases such as Parkinson-Plus arise when particular proteins accumulate that are not folded properly. Our research goal is to understand the links between these diseases and autophagy — the bulk recycling process that degrades proteins and particular parts of the cell. We currently focus on: understanding how autophagy is induced using several animal models; and possible ways to ramp up this process in order to remove toxic proteins and avoid the development of neurodegenerative disease.
Publications
FH Siddiqi, FM. Menzies, A Lopez, E Stamatakou, C Karabiyik, R Ureshino, T Ricketts, M Jimenez-Sanchez, MA Esteban, L Lai, MD Tortorella, Z Luo, H Liu, E Metzakopian, HJR Fernandes, A Bassett, E Karran, BL Miller, A Fleming and DC Rubinsztein (2019) Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing. Nature Communications 10:1817
Please see my google scholar profile for a full publication list.
